Diabetes-induced mechanical hyperalgesia involves spinal MAPKs activation in neurons and microglia via NMDA-dependent mechanisms
نویسندگان
چکیده
INSERM U766, Facultés de Médecine et de Pharmacie, Clermont-Ferrand, France (LD ; CM ; CC ; ME ; ED ; AMP ; AE ; JF) ; Université d’Auvergne Clermont 1, Faculté de Pharmacie, Laboratoire de Pharmacologie, Clermont-Ferrand, France (LD ; CC ; ED ; AMP ; JF) ; Université d’Auvergne Clermont 1, Faculté de Médecine, Laboratoire de Pharmacologie Médicale, Clermont-Ferrand, France (CM ; ME ; AE) Molecular Pharmacology Fast Forward. Published on July 25, 2006 as doi:10.1124/mol.106.025478
منابع مشابه
Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms.
Molecular mechanisms underlying diabetes-induced painful neuropathy are poorly understood. We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord...
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